779
1241308026012657110168
INTERVENČNÍ341804301071978123168215263308366420478499
A8628043010752
AKUTNÍ936804301075299157202263284
KARDIOLOGIE12418043010745103150211232295337397456477520
/18078043010732
Interv188480430107196794136163207
Akut2110804301075391139168
Kardiol.2297804301074588114162181229249264
2023;22(3):122-1282581804301074487128172186230274296338359374411448492518556594636
/32628043010732
www.iakardiologie.cz48438043010765133201214233274312354380428447495515563613632675690730769
PŘEHLEDOVÉ341207012660124182256312369444520587645
ČLÁNKY1008207012660115187259327395
/1424207012633
REVIEW1477207012662121191224282376
ARTICLES1874207012668131191224287342399458
Treatment3413650106306698139168221253294327
options68336501063974106123164206238
of93736501063869
in‑stent10223650106155684114147179220253
restenosis:129036501063466100133165206247280297329345
mini164936501065270111128
review179336501063365105122154215
injury3406210109217092141170215
due57162101095099145
to73162101093078
the82562101093079125
persistent96562101095197127163184219249294344373
„abuse“135462101093176127177212257289
exercised165962101094587131161201222257302353
by34076101095397
a464761010944
foreign53676101092779110157180233285
element84876101094670117196243296327
causing120276101094188139176199251304
chronic153376101094193124176228251293
wall1853761010969114137159
stress3409010109366796141177213
due573901010950100146
to73890101093079
media837901010975121173194237
damage109490101095194170213264310
and142390101094494145
stent158890101093667111162191
struts17999010109366696146177213
protrusion340104101095181131161191241277298348399
in765104101092171
tunica861104101093080130152193237
intima.1123104101092272101123198242261
These1410104101094596142178224
stimulate165910410109366788163213235279308353
inflammatory34011810109217197121164239314357387435465511
processes867118101095180130171215251286332367
and1250118101094393144
the1410118101093080125
migration1551118101097596146176220249270320370
of1937118101094975
smooth3401321010936111161211241291
muscle6561321010975125160201223268
cells949132101094185107128164
from1138132101092656106182
tunica1345132101092979129150191235
media16051321010975121173194238
and1868132101094393145
myofibroblasts3401461010974115163189213263292341392414456491522558
from913146101092656105179
tunica1108146101092978127148188231
adventitia1355146101094393137180230259279309330372
to1743146101092977
tunica1836146101092978128148340160101094085
intima.445160101092171100121197240260
Simultaneously,725160101094465140190211241286336381432482518539582597
the1342160101093080126
vessel1488160101094388124159205227
discontinuity1735160101095172108149198248340174101093051101151172203248
created613174101094171116160189234286
by925174101095194
stent1044174101093667112162192
struts126117410109366797147178215
may15011741010975119161
facilitate1687174101092771112133155176206251280325
contact340188101094089140169213254286
between648188101095197128196241288338
the1008188101092979125
two1155188101092998147
distal1324188101095172108138183204
layers1550188101092165106151181217
of1789188101094976
the1887188101092979125
vessel340202101094388124159205227
wall5882021010966110131153
with761202101096788118168
blood950202101095173123174226
elements,1196202101094567113189235285314351371
resulting1587202101093075111160182212233283334
in1941202101092272
various340216101094386115136185234269
stimuli62521610109356586160208229250
for890216101092675104
neointimal1010216101094994144165214243263337380401
proliferation1426216101095180129150171197242271314343364413463
(3).190421610109256992108
While3402301010976126147168213
DESs5692301010959104149183
minimise768230101097495145166240261297342
neointimal1126230101094995145166215245265340383404
proliferation1546230101095181130151172199244273317346367416466
compared340244101094089165216260290335387
with745244101096788118168
BMSs,9322441010948121165200220
hypersensitivity1170244101095091143190220256302353388409439460504526556601
to1790244101092978
the1887244101092979125
polymer3402581010952104127171250297328
and694258101094496149
the869258101093182129
drug,1025258101095282134186206
local1258258101092173115161183
inflammation,1468258101092173100125170247324369400421473525545
and340272101094391141
delayed496272101095094115158198241292
healing803272101094993135156176225274
are1092272101094371115
the1222272101092978122
main13592721010974116136185
contributors1559272101093987136164193214263312341389418453
to340286101093079
neointimal438286101095096146168218247268343387408
formation866286101092676106181225255276326376
with1261286101096788118168
DES‑ISR14482861010960105151181204249297
(1).176428610109256887104
In480300101092172
addition,568300101094394145166196217267318336
neoatherosclerosis921300101094995145189219269314344394429470491537566616651672708
is1645300101092156
suggested1717300101093685136186232268340314101093074126
as482314101094378
another576314101094493143173222268298
cause890314101094084133168214
of1120314101094975
very1211314101094388118163
late139031410109216494138
stent1544314101093666111161190
thrombosis17503141010930801091582333403281010951102137158194
and555328101094393145
late72132810109216494139
target881328101092974103154200230
lesion1132328101092167103124174224
revascularisation1377328101092975118162197238288309353383404440484514535585635
(12).340342101092670112137155
It522342101092253
is602342101092259
related688342101093077100146177223277
to992342101093181
incomplete1100342101092274116167245299322369401447
regeneration15743421010931781311782312783103553864093403561010950101
of466356101095077
the568356101093081127
endothelium721356101094596147198228278324347368418493
leading1240356101092268112163185235286
to1552356101093079
excessive1657356101094588128173209245267311356
uptake3403701010950102133178221266
of632370101095077
circulating73537010109416293133184206250280302352404
lipids116537010109214395117169205
and1396370101094495147
accelerated1569370101094486126171193240270315345391443
development340384101095299144190212264317395442494525
of892384101095078
atherosclerotic996384101094575127174205256293335358405436487518540582
plaques1604384101095376121173225272309
in1939384101092273
the340398101093080126
nascent489398101095093129170214265294
neointima806398101095096147168218248269344387
(3).121739810109257093110
It1350398101092252
can1425398101094084134
occur1583398101094990130180209
years1815398101094388131161198
after340412101094370103148177
stent534412101093566111161191
placement741412101095173117157202277323373403
and1160412101094394145
is1321412101092157
characterised1394412101094090133163207248280324354376411457509
by1919412101095194
accumulation340426101094587128179257309331376407429481533
of900426101095179
lipid100542610109224497120173
foamy1205426101092779124202245
macrophages14774261010977122165195247300353398451498535
within340440101096586115164184233
the588440101092978122
neointima,725440101095094143164213241261335377396
with1136440101096586115164
or1315440101094877
without1407440101096586115164213262291
necrotic1713440101094994134162211240260299
core340454101094089119164
formation,523454101092777107182226256277327377396
and938454101094494145
calcification1102454101094085106147168195219259303333354404455
(13).1576454101092567108131148
Neoatherosclerotic4804681010960106157202232283329359409445487508555585635665687728
change1234468101094091135186237283
in1543468101092172
the1641468101093080127
restenotic17934681010930761121431893404821010951103134155197
tissue56448210109315389126177224
is815482101092158
recognised900482101093076119169222274296333380433
earlier1360482101094691122144166213244
and1631482101094496149
more18074821010976128159206
frequently340496101092657102154204250300330351394
in760496101092171
DES‑ISR.8564961010960105151181204249297318
An12004961010955105
optical13314961010949101131152193237259
coherence1615496101094189140186216261312353397
tomography340510101093079154204256286330381432473
(OCT)833510101092686140187216
study1069510101093666116168211
demonstrated1300510101095197172222273308339369413442487539
that1860510101092979123153
homogeneous340524101094998173222272317366411461510545
and900524101094392143
lipid‑laden105852410109214192113163191214256307351401
neointima1474524101095094144165214243263337380
was18695241010966109144
usually340538101094984132174195216258
found613538101092574123172222
in850538101092170
the935538101092978123
BMS10735381010948119163
early1251538101094487115136178
phase14445381010951100143178222
(≤1681538101092676
117725381010945
year)1832538101094286128157180
and340552101094394145
late50855210109216494139
phase6705521010951102145181227
(>920552101092577
110195521010947
year),1088552101094388131161185202
respectively;1313552101092975110162208249282303346391413456475
heterogeneous1811552101095096126171340566101093082136183236284336389426
neointima794566101095299152175227258280358404
was12265661010968114151
observed14055661010951105143191222270317371
more18045661010977130161208
frequently340580101092657103155205251302331353396
in762580101092171
the859580101093080126
DES10115801010960106151
early1188580101094589119141184
phase13985801010951102146182228
(≤1652580101092577
117555801010946
year)1827580101094388131161186
compared340594101094089165216260290335387
with746594101096687118168
the932594101093080126
BMS10765941010949121166
early1260594101094589119140183
phase14625941010951102145181227
(44%1707594101092669118188
vs.191459410109437999
9%,3406081010946119139
P4986081010948
<5656081010954
0.05)638608101094664111157181
(12).838608101092668108132149
Clinical3406330014771101132201232286348380
Presentation7476330014767109172222285355397459501532600669
of14436330014768107
ISR1577633001473295164
ISR480650101092267116
may6226501010977121164
remain812650101093076153197219270
asymptomatic1108650101094481125203255286336413458488510551
or1686650101095080
cause1793650101094186136173219
symptoms340664101093578152202231279353388
and743664101094291141
any899664101094392132
objective1046664101094999120165205236256299343
evidence1404664101094486107157202251291334
related175366410109297394136165209259
to340678101092977
myocardial4326781010975115163203247276325346388409
ischaemia.85667810109215696145187232306327369388
Clinical125967810109527292141162201245265
presentation1540678101095079124159203253281325354374423472
during3406921010951102132154205257
hospitalisation6246921010950101137190212243288310332368413444465516568
is1218692101092157
classified1302692101094062107143179201228253299352
into1680692101092273103153
ACS18596921010956107153
and340706101094394145
non‑ACS.5077061010950100151180235286331350
Stable880706101094473117168190236
angina1138706101094494145166216259
manifests14207061010975118168190216262298329366
as1808706101094379
typical1909706101093075340720101095071110153174
chest528720101094088133167197
pain740720101095093113161
occurring916720101094989127175204233253302351
on1282720101094897
physical13947201010950100140174194234277297
exertion1706720101094486129157189209257306
and340734101094394145
relieved51073410109297496117163206251303
by837734101095294
rest955734101093075111142
or1122734101094979
nitrates.1226734101095071101131175204249285305
Silent155573410109456587132183212
ischaemia1792734101092157981481913407481010946122144188
can554748101094186137
be717748101095299
identified842748101092173120171201222250274321373
by1241748101095295
abnormal1362748101094496147198229306350372
results1760748101093076112162184215252
during3407621010951100130152202252
stress61676210109366696141177213
tests852762101093075111142178
(treadmill105476210109265483128172224299320341363
exercise1440762101094588132162203224259305
test1768762101093075111142
or1933762101095080
dobutamine340776101095099150199228271345366415459
echocardiography).815776101094485133182223266295344365414464493536586636676700716
Unstable15467761010958106141171214265286331
angina18927761010943922140286101095072122165
is2322286101092157
defined2396286101095096123147197243295
as2708286101094379
typical2804286101092975127148189233255
chest3076286101094090136172202
pain3295286101095296117167
of3479286101094976
recent3572286101092975116161211240
onset21403001010950102138185216
or2382300101095181
increasing2490300101092172114144191235272293344396
in2913300101092172
duration30113001010952102133178208230281333
or3370300101095081
intensity3477300101092173103149200236258289335
two2140314101093099148
weeks23143141010966111158201239
before2579314101095198125175205251
hospitalisation.28553141010950101136188210240284306327363407437458509559579
This3459314101094597118154
type3638314101093075128174
of2140328101094976
angina2239328101094394144166216259
is2521328101092157
refractory2601328101092974102132176217249298328374
to2998328101092978
medications31003281010975120172194234278308329379430465
and3588328101094394145
is3756328101092156
associated2140342101094379115165206227271300345397
with2559342101096788119169
ST‑segment2750342101094490115151197248323369420449
ECG3222342101094496152
abnormalities.3396342101094495146196226301345366388214035610109295094129148
MI2303356101097193
is2411356101092155
categorised2481356101094083112156206255284305340384435
into293135610109217098146
STEMI3092356101094489133204225
(ST‑elevation3332356101092667112136182204248290333362382431481
myocardial21403701010976119169211256287339361405427
infarction)259437010109217299145175216249271322373397
and3018370101094495147
NSTEMI31923701010960105152198272295
(non‑ST3514370101092674125177207252298
elevation2140384101094466110152195224244293342
myocardial24973841010974114162202246274324344387407
infarction)291938410109217096139168207238258307356378
based3312384101095194129173224
on3551384101094998
ECG3664384101094494149
dynamic2140398101095092141183256277316
abnormalities2471398101094292141190219292335355375404424468503
and2989398101094291141
elevations3145398101094465109151193222242290339374
in3533398101092170
high­3617398101094969119167195
‑sensitivity2140412101092865111162198220250272316338369415
troponin2581412101093060110163214265287337
levels.2944412101092268112157180216236
Magalhaes32054121010973118170214236286331377413
et3644412101094677
al3747412101094365
conducted2140426101094087136186234273304348398
an2553426101094291
observational2658426101094999134178207252294323343391440483503
study3176426101093565113163204
to3395426101092977
compare3487426101093986160210253281325
the2140440101093080126
clinical228744010109416283133154195239261
presentation2570440101095181126162208258288332362383433483
among30754401010943119169219270
three3367440101093080109155201
generations35904401010950961461922140454101093074104126176227263
of2429454101095077
stents:2531454101093668113164194231250
BMS;28074541010949122167185
first‑generation301845410109265080117149175228274325372402446476498548599
DES;36434541010961106152169
and2140468101094496149
second‑generation2316468101093683126176228281312366413465513544589620642693745
DES.30884681010961108154174
They3289468101094699146189
showed3505468101093788140208254307
that2140482101093082127157
ISR2324482101092267117
clinical246848210109416385136158200245268
presentations2762482101095384130167214266297342373395446498535
in3323482101092273
all342348210109446789
groups3538482101095182133185238274
were21404961010966111141186
similar,2349496101093556131153174218247262
with2634496101096687118168
ACS28244961010955105151
accounting2997496101094484124173223273302323373424
for3444496101092676106
67.8%,3572496101094790101148220240
71%,2140510101094690156176
and2334510101094393144
66.7%2496510101094693113158230
in2743510101092171
BMS,28315101010949121166185
first‑generation303351010109265080116147173226272322368398442472493543593
DES,36435101010960105150169
and2140524101094597151
second‑generation2321524101093785129180233286317373420473521553599630653705758
DES,31105241010961109156176
respectively.3317524101093078115169217261295318364410434479495
Although2140538101095576106155205255305355
not2511538101094999128
statistically2655538101093666110140160196226247287331352373416
significant,3087538101093556106156177203227267311361390409
second­3512538101093581122170220271300
‑generation2140552101092881126177223252297326347397448
DES‑ISR26085521010960105150180204248296
patients2924552101095296125146192242272309
were32535521010966111141186
less3460552101092167103138
likely361855210109224385129151194
to2140566101093079
present2244566101095181127162208259288
with2557566101096788119169
MI2751566101097294
compared2871566101094089164216260290335387
with3283566101096688118168
BMS34765661010949122166
and3667566101094494145
first‑generation214058010109275182119151177232278330377407453483505556607
groups2774580101095181132183236272
(5.2%307358010109267190139212
versus3311580101094490121158209245
10.6%3583580101094690109157229
and2140594101094394145
10.1%;2304594101094689107148214233
p25565941010951
=26265941010954
0.273)2699594101094665113158203226
(14,2944594101092668109128
15).3091594101094687111128
Imaging21406190014732134196265296365434
for26026190014738106150
In‑Stent27796190014732101141201242303373415
Restenosis32216190014768131182225286356424474505556
Stent2140647501435690147211246
Enhancement24156475014356119183237301355411509568632667
Conventional22806641010952100151193237287316337387437481502
angiography2798664101094393144165214266295339390440482
may32956641010975119160
fail347166410109267091112
in3599664101092171
detecting36866641010951962140678101093074115146167216267
stent2422678101093666110160189
underexpansion2627678101094998149194224268311362406455490511560610
and3252678101094393144
has3411678101095093128
low3554678101092271136
accuracy37066781010943832140692101094090120164204249
in2407692101092171
assessing2496692101094379114160196231252303353
correct2867692101094089119149194236268
stent3152692101093667112162192
positioning.33616921010951102138159189210260310331382432451
This2140706101094596117153
technique2314706101093074116166216237288338384
works27197061010966115145188227
by2967706101095193
identifying3082706101092172118168198219246292314364414
the3518706101093079125
two3665706101092998147
markers21407201010977122152196242273311
of2478720101095078
a25837201010944
balloon2654720101095298120142193245297
positioned29787201010952105142163195217268320367421
inside3425720101092273110132185232
the3683720101093182130
stent.2140734101093566110159188207
Throughout2363734101094495124172222272321370420450
the2828734101093079124
respiratory2967734101093074109160181210253282331360405
and3388734101094392143
cardiac3546734101094084113163184226266
cycles,2140748101094186127148195231251
the2417748101093080127
two25697481010931100150
markers27457481010975120150193238268306
move30777481010975126169215
in3317748101092272
synchrony3415748101093681132174224254304355397
with2140762101096688118168
the2333762101092979125
metallic24837621010975121151196217238259300
struts.280876210109356696146176213233
Stent3065762101094573118169198
Enhancement3288762101094494144187237278323398444495524
(SE)2140776101092568111137
has2293776101095093128
100%2437776101094688136208
specificity2661776101093586132173194221245285306336380
compared3057776101094089164215259288333385
to3458776101092978
IVUS3552776101092172131174
in3742776101092171
identifying3940286101092172118168198219246292314364415
stent4379286101093667111162191
underexpansion.45952861010949100151196226272315366411461496517567618637
The5256286101094596142
main54222861010975119140190
limitation3940300101092142117139169213243264314364
of4326300101094976
SE4424300101094488
is4534300101092157
that4612300101093080124153
it4787300101092151
only48603001010949100121164
visualises5046300101094465101150194215236272318354
stent5421300101093667112162192
struts,394031410109356695145175212231
and4186314101094493144
cannot4346314101094084134183233262
provide4624314101095181130172194245290
information493031410109217096146176251294323344394444
regarding53903141010929741251681973940328101095172122173
the4132328101093080125
vessel4277328101094387123159205227
wall45233281010966110131153
and4695328101094393144
plaque4859328101095173116168217263
(16,5141328101092668110129
17).5289328101094686112129
Intravascular3940353501432589125160215268323367421485510564599
Imaging:45673535014326124178243268332397417
IVUS5013353501432587163216
and52583535014355119184
OCT39403675014381150210
Intravascular4080384101092171100130173215259294334383405448477
imaging4573384101092195138189210259310
can4898384101094084134
be5047384101095197
a51603841010943
useful5219384101094984130156207228
tool5463384101092978128149
to3940398101092977
guide4033398101094998119169214
coronary4262398101094088117165215258287331
stent4608398101093666110159188
implantation4811398101092195145167209258287331359380429478
because5305398101095095136179228263308
of3940412101094975
angiography4031412101094393143164213264294337388438479
limitations4526412101092142116137167211240261310360395
(18).4937412101092567109133149
OCT51024121010962115162
and5279412101094493144
IVUS5439412101092171130173
offer3940426101095077107153183
an4149426101094394
anatomic4269426101094394138168217293315356
assessment4651426101094379115161198234309356406436
of5113426101095077
the5215426101093081127
vasculature5368426101094388124165215394044010109216594144174219
and4183440101094393145
allow435244010109436486136202
visualisation4577440101094466101150194216237272317346367417468
into5069440101092171100149
the5242440101093080126
heart.5391440101095096140169202221
Both3940454101094999129179
techniques4141454101093075116166216237289338384420
are4583454101094373118
used4724454101094985131183
to4929454101093079
make50304541010975119161205
measurements5258454101097512116420024927932439404681010975121171201238
for4203468101092676106
lesion4335468101092167103124173224
length4584468101092267118169199249
and4858468101094494145
lumen5028468101092271147192243
size,529646810109365796141160
but54814681010951101131
OCT39404821010964119168
is4135482101092158
being42204821010953101123175228
shown4475482101093688140208261
in4762482101092274
studies4863482101093668120173195243280
to5170482101093081
be52784821010953100
more54054821010977129160207
accurate3940496101094384124173203247277321
(19).4281496101092567108132150
Intravascular3940521501432589125160215268323367421485510564599
Ultrasound45675215014376100137173228272337401464530
(IVUS)5126521501433256118195248279
IVUS4080538101092275137182
is4289538101092259
a43755381010945
medical44475381010977125179201244290312
imaging4787538101092199145197220272325
method51395381010977125157209261315
designed548153810109521003940552101093657107157203255
with4213552101096688118168
a43995521010944
miniaturised4461552101097596146167211240290320341377423475
ultrasound4954552101094971101130174210260310360412
probe5384552101095181130182228
attached3940566101094373105149190240286337
to4294566101092978
the4388566101093080126
distal4530566101095172107138182204
end4750566101094596147
of4913566101094976
a50055661010943
catheter.5065566101094084114164209240284314329
It5411566101092151
can5478566101094185135
show3940580101093585134200
full‑thickness415558010109267698118147177226247287329380425461496
visibility466758010109436499120170192213233263308
of4990580101095076
the5081580101093079125
vessel5221580101094387123158203225
wall54625801010965109130151
by3940594101095295
generating4062594101095197149196227272302324375427
sound4515594101093788139190243
waves47845941010968112156201238
that5049594101093081126156
penetrate52315941010952100151198230260305335381
4-83940608101094677125
mm40836081010975150
inside4250608101092171106127178224
the4490608101092979125
vessel4631608101094388124159205227
wall.48746081010966110131152171
This5061608101094596117153
technique5230608101093074116165215236287337383
can3940622101094186137
evaluate4103622101094690134156207251281327
the4456622101093081128
extent4610622101094589122168219249
and4885622101094495147
distribution5059622101095173109140171193245296327348399450
of5535622101095078
neointimal3940636101094994144164213242262336379400
tissue435563610109295084119167212
within4582636101096586116165185234
the4831636101093079123
stented4970636101093565109158187230281
segment,5266636101093680131205249299328346
but39406501010952103134
is4101650101092157
limited4185650101092143120142173218271
to4483650101093080
visualising4589650101094467103154198220242279300351403
its501965010109215290
complex5135650101094191168221243290334
tissue5495650101093052893940664101093685131
structure409566410109366696146187219269299344
as4463664101094379
can4566664101094185135
be4725664101095198
documented48476641010951101142192267313363393437489
by5361664101095193
histopathology.54786641010950711073940678101093182136182213265317340392446491507
Therefore,4475678101094699147178225254306337384404
it4906678101092253
enables4987678101094699144197221268306
pre‑PCI5320678101095384132163216270292
assessment3940692101094379115161197232308354404434
of4399692101095076
plaque4501692101095173117168218264
burden,47906921010952102132183228279298
the5113692101093080126
extent5265692101094588121165216246
of5536692101094976
calcification,3940706101094084106146167194218259303332353403454472
lesion4429706101092166102123173223
length,4669706101092166117168198248267
and4952706101094393144
external5113706101094587120165195245289310
elastic5439706101094567111146394072010109305191
lamina4051720101092165140161211255
diameter4326720101095072115190236267311341
for4687720101092676106
stent4813720101093566111161191
sizing502472010109355695117167217
as5261720101094379
well53607201010966111133154
as5534720101094379
post‑PCI39407341010951102138168194244297318
assessment4279734101094379114160196232307353403433
of4733734101094976
minimum4830734101097596146168243292368
stent5219734101093666111162191
area,5431734101094473119162182
malposition,39407481010977123147201254292315347370422476496
underexpansion,44717481010951104158206238286332386433486523546599652673
tissue517974810109305391129181229
protrusion,54437481010953851373940762101093060111148169220271291
edge4257762101094598150196
disease,4479762101095173109156200236283302
and4807762101094495147
edge4980762101094598150196
dissection.5202762101095173109146192234267289339391410
A39407761010955
situation401677610109365787137180210231281332
where43697761010966117162192238
IVUS4628776101092172131175
is4824776101092257
a49027761010944
suitable4967776101093685106136181232254300
choice5288776101094090140162202247
is5556776101092157
Figure214061901124771125178213262
1.242061901125070
Clinical25356240107486685131149186230248
Presentations280062401074267104135172219244287313331376423452
of326962401074568
ISR33536240107195698
Clinical2729156201436893117181205259314339
Presentations2577169201436094151196255319354409445470534598642
ACS38201230014370136193
Non-ACS37152054014377141206243313378435
Unstable4722943014375138182221276342368426
Angina47641073014370134200225288342
Myocardial46821377014393146209264319354418443496521
Infarction4714150701432589120176211263303328392456
Stable4794180501435690145211237296
Angina47711935014370134200225288342
Silent4804221701435680104163227262
Ischaemia4698234701432569123186240299397422475