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12556558026012657110167
www.iakardiologie.cz3408043010765133201214233274312354380428447495515563613632675690730769
/26598043010732
Interv273680430107196793136162206
Akut2962804301075391139167
Kardiol.3149804301074587114162180228248264
2023;22(3):122-1283433804301074487128172186230274295338359373411448492517556593636
/41148043010731
INTERVENČNÍ4191804301071978123168215263308366420478499
A47128043010752
AKUTNÍ4786804301075399158203263284
KARDIOLOGIE50918043010745103150211232295337397456477521
PŘEHLEDOVÉ3620207012660124182256312369444520587645
ČLÁNKY4287207012660115187259327395
/4703207012633
REVIEW4756207012662121191224282376
ARTICLES5153207012668131191224287342399458
Treatment39453650106306698140168221253294327
options428736501063974106123164206238
of454136501063869
in‑stent46263650106155684114147179220253
restenosis:489436501063466100133165206247280297329345
mini525336501065270111128
review539736501063365105122154215
in34062101092171
a431621010943
patient49462101095296125146192242272
with78662101096688118168
very97462101094388118163
severely115762101093682125169199245267310
compromised148762101094089164216246295371392428473525
renal34076101092973123165186
function54176101092676125165196217266315
and87176101094392143
to102976101092977
minimise112176101097595144165238259294339
the147576101092978123
use161376101094984129
of175776101094975
contrast18477610109408813734090101093059103139170
in52990101092171
PCI619901010948101122
(18,76090101092567109129
19).90890101094687111128
Optical3401155014381148184209262318343
Coherence7111155014369131196254289346410464521
Tomography12601155014356113211276342377433498563614
(OCT)3401295014332110179240276
OCT4801461010962116165
gives668146101095073117163200
an891146101094395
image1009146101092197142193240
resolution1272146101093076113164187237268290341392
101688146101094689
times1801146101093052128174211
greater340160101095284133180212260293
than668160101093184131184
IVUS887160101092277140187
and1109160101094498153
is1297160101092160
also1392160101094468107160
easier1587160101094794132156205238
and1859160101094599153
faster340174101092672108140185216
to581174101093080
set686174101093683114
up8251741010950102
and952174101094395147
use.1124174101094986133152
It1301174101092253
reconstructs1379174101092975118167219255287318369410443481
the1885174101093081128
vessel340188101094592131169218242
wall6111881010969115139162
image8031881010922101147201250
by1082188101095398
using1210188101095189112165219
infrared1459188101092275103136183215263318
light.180718810109224599152184206
This340202101094597119155
light‑based51720210109224495146176203256302338385438
OCT9772021010962116164
technology1163202101093076118169220271294345397441
can1626202101094186137
penetrate1785202101095198150196340216101093061107138184
2-3552216101094674121
mm6942161010976153
inside874216101092273110133185233
the1134216101093082129
vessel1291216101094490127164212235
wall.15542161010967112135157178
OCT17602161010962117166
is1954216101092158
far340230101092672102
better462230101095299130163209240
than722230101093080125176
IVUS918230101092274134178
for1117230101092677108
determining1245230101095197129174205282304355377428480
the1745230101093080127
vessel’s1892230101094489340244101093673120143164198
luminal565244101092172149171222267290
diameter882244101095174118195242274320351
and1260244101094495148
cross‑sectional1435244101094171122159196225262309352385407458510555577
area.340258101094476124170191
OCT5592581010964120170
can757258101094288141
depict9262581010952100155178221255
plaque1210258101095276122176228276
morphology15152581010976129161215269321345398452497
with340272101096689120171
a5372721010943
sensitivity606272101093683134171192223245290313344390
close1022272101094163114150197
to1245272101093080
that1351272101093081125156
of1533272101094977
histology.1636272101095072108140190213264316360376
It340286101092254
can423286101094188141
also593286101094468106158
assess780286101094583121169207245
calcium1054286101094188112155178230309
thickness,1392286101093083106149194248297335373394
lipid,181528610109224599122176197
thrombus,340300101093082113165243296348385406
fibroatheroma,774300101092752106137189235266318365397448526572593
plaque1395300101095275120174225273
rupture,1696300101093082135167218250297316
stent340314101093667113164194
strut55231410109366898149180
neointimal750314101095097148170221251273349394416
thickness1184314101093080102144187239286322359
and1561314101094394146
apposition,1725314101094396148200236258340328101092951100150170
and526328101094393144
edge687328101094496146192
dissections.896328101095071106142187229261282332382417437
It1350328101092151
requires1418328101092974125175196226271306
the1741328101093079125
use1882328101094985130
of340342101094976
contrast433342101094089139169199243279310
injection76034210109217193139180213234284335
and1112342101094393145
may12743421010974118159
not1451342101094999129
be1598342101095097
suitable1712342101093584106136181232255301
in340356101092172
the430356101092980127
case575356101094085121168
of761356101094976
patients855356101095196127149195246277314
with1187356101096689120171
severe1376356101093582126171202248
renal1642356101092975126171193
dysfunction1853356101095094131340370101092678129171204226276328
(18,689370101092568111132
19).842370101094688113131
Based480384101094892127172223
on719384101094898
restenotic833384101092973109139183233282311332372
tissue122038410109305085120169214
structure144938410109366695144185216265294339
in1803384101092170
the1889384101092979124
cross‑sectional340398101094070119155191218255300342374395445495539561
images921398101092196140190236272
captured1213398101094185136166216246291343
by1576398101095194
OCT,16903981010962115163177
the1887398101093080126
patterns340412101095195125157202232283318
are677412101094473118
categorised814412101094185115159211261291312348394446
into1279412101092171100149
(20):1447412101092671116141159
1.340426101094661
Homogeneous4804261010960113192244297345398446499551588
intima:1097426101092274105127205251271
uniform13964261010951104126154207238317
optical17424261010951105136159201247270
properties480440101095180128179224253285305350385
of880440101094975
restenotic970440101092973108138182231280309330369
tissue135444010109305085120168213
showing1582440101093584133197218267317
no1914440101094998
focal480454101092675116160181
variations677454101094387116137180209230279329364
in1057454101092171
the1143454101093079125
backscatter1283454101095195135177215256299329360405434
pattern1733454101095195124156200229279
2.340468101094666
Heterogeneous4804681010959105135180210259311356407453503553589
intima:1088468101092171101122197241259
a.340482101094363
Type480482101094582134179
16754821010946
–7374821010945
Thin‑cap798482101094495116166195237281332
fibroatheromas1146482101092650101130179223253302348377426502545580
(TCFA)-1742482101092573123166217241270
like48049610109214285129
pattern:628496101095196125157202232283301
the948496101093080125
presence1093496101095181126162208258299343
of1456496101094976
an1551496101094393
area1663496101094473118162
with1844496101096688118168
marked4805101010975119148191235287
signal789510101093556107157201222
attenuation1032510101094473105150201250294323344394445
with1498510101096688118168
a16875101010944
diffuse175251010109507299128179215260
border4805241010952103134185232262
and768524101094495147
fibrous941524101092651103133183234270
cap1237524101094186138
thickness1401524101093081103144187239285322358
at1785524101094474
the1885524101093081127
thinnest480538101093080101151201247283314
part815538101095296125158
≤9955381010954
651070538101094792
μm11815381010949125
and1328538101094393145
an1495538101094393
angle1610538101094393144166211
of1843538101095076
lipidic1941538101092142480552101095173124145186
tissue68555210109305186122171217
≥9215521010954
180°994552101094688135166
b.340566101095169
Type480566101094684138186
26935661010947
–7675661010946
Layered839566101094490133179210257310
pattern:1176566101095298128162208239291310
restenosis1513566101093076113145192244295332354391
tissue1930566101093153480580101093774126174
consists683580101094293145183205242275314
of1026580101095179
concentric1135580101094192145188234287318350373415
layers1580580101092267111157189228
with1837580101096891123175
different48059410109517299129174204249300330
optical8355941010949101131152193237259
properties1119594101095282131183229259292313359395
(a1539594101092667
thick1631594101093080101142184
high1840594101095072122172
scattering480608101093576120149181226255277327377
layer873608101092164106150180
and1069608101094393144
a12296081010943
low1288608101092171136
scattering1440608101093576120149181226255277327377
layer1833608101092164106150180
with480622101096688118168
a6676221010943
stent730622101093566111161191
strut)94062210109356696146176201
c.340636101094060
Type480636101094481132177
36726361010945
–7326361010945
Patchy792636101094789117156205245
pattern:1052636101095194122154197226276293
patchy1360636101095194123161210250
and1625636101094392142
highly1782636101094970119168189231
echolucent480650101094586135184206255295339389418
regions913650101092974125146195245280
throughout1208650101093079108157206257306355405435
the1658650101093079124
layers1798650101092164105149178214
d.340664101095170
Type480664101094582134181
46816641010946
–7476641010945
Speckled813664101094495142183225248294346
pattern:1179664101095195125157202232282301
restenotic1500664101092975110141186237286316337378
tissue189866410109305187480678101093584130
consists625678101094089139174195230260297
of938678101094975
a10296781010943
heterogeneous1088678101094995125169199248299344394439489539574
speckled1678678101093686132173215238283334
band.480692101095195146197216
Management3407170014799161230292361424526589659701
of10687170014768107
In‑Stent12027170014732101140200242303373415
Restenosis3407310014768131181225286356424474505556
The480748101094597144
treatment650748101093060106150180256303354384
of1060748101095077
ISR1163748101092267116
remains1305748101093075152196218269305
a16367481010944
challenging1706748101094091135157179225276340762101095173124176
clinical54276210109416385136158200245267
problem.835762101095283134187209256333353
Clinicians121476210109547597148170211233278329365
should1606762101093687138189211264
carefully1896762101094186340776101093077106159181204249
consider616776101094292145182204258305337
choosing980776101094294146198235258310363
the1370776101093183130
best15287761010952101138171
type1726776101093178132180
of1934776101095179
treatment214062101093061107152183260307359389
based255662101095298134181235
on2817621010951103
the294662101093082129
original310162101095182104156178230274297
stent342462101093668114166197
problem364762101095283134214076101095376123202
to236976101093081
prevent247776101095385132177223275306
the281076101093183131
possibility2968761010952105142179201255278300322354401
of339676101095179
another350276101094496148180232279310
recurrence.214090101092975116166195226271321362407425
Drug‑Eluting21401150014782126195264303368400468511542611680
Stent28471150014762104165235277
(DES)31511150014736117180243278
Most22801321010975127164197
previous2504132101095384131177200252304341
studies2872132101093770121175197245282
consistently3182132101094192145182204241274320373404426471
demonstrated3680132101095310021401461010977131184223256288335367415470
relatively2652146101093078103149181205252299324370
poor30631461010953107160193
outcomes32971461010951105137180232311360399
in3737146101092275
patients2140160101095196125147192243272309
treated2475160101093060105149178223275
for2776160101092676106
DES‑ISR29081601010960105150180204248297
compared3230160101094189165217261291336388
with3644160101096688118168
BMS‑ISR21401741010949121166196219264312
(21).2468174101092671113132150
In2634174101092172
a27221741010943
meta‑analysis27811741010976121152196225269319363384427463484520
assessing3317174101094379114160196232253303354
the3687174101093080125
treatment2140188101092958101143172245289338366
of2520188101094974
DES‑ISR,26091881010958102145174196239286306
repeat2929188101092973123167209238
DES31811881010959102146
implantation3341188101092194143164206255283326354374423471
showed2140202101093688139206252306
decreased2472202101095298141171218263299346399
target2898202101093075106158204236
revascularisation3160202101093077121166202245295318362393415452497528550601652
and2140216101094391141
superior2296216101093583132177206227275304
antirestenotic2615216101094291119139168212246276319368417446466505
efficacy313521610109447099122161204243287
compared3436216101094087161211254282326376
with2140230101096688118168
angioplasty2324230101094393144165215267289332368398443
alone.2784230101094364114165210229
DES30292301010960105150
implantation3195230101092196147169213263292336366387437487
exhibited36982301010945882140244101095071122143173218269
similar2425244101093657131152173217246
performance2687244101095197127156206235311354404445489
in3192244101092170
both32782441010951102131181
ISR3475244101092165113
types3604244101093075127173209
(BMS‑ISR2140258101092674147191221245289337
or2496258101095080
DES‑ISR)25952581010960105150180203248296321
(1,293525810109266882
22).3036258101094693116133
A22802721010955
large236127210109216595145191
meta‑analysis25782721010975121152196225269319363385428464485521
was31242721010967111147
conducted3296272101094190140192242283315360412
to3733272101093080
clarify2140286101094162107137159186233
which23992861010967118140181232
strategy265728610109366898143173218270315
is2998286101092157
the3081286101093081127
best3234286101095299136167
treatment3427286101093061106151181257304355385
modality21403001010975125177221242263293338
for2499300101092676106
ISR.2626300101092166114135
The2782300101094495141
study2944300101093566116167211
involved3175300101092171114162184228273325
273520300101094691
trials363130010109306081125146182
with2140314101096892124176
a23483141010945
total2425314101093082114160182
of2638314101095178
5,9232746314101094866112158205
patients2982314101095298128150197249280318
at3330314101094475
634353141010948
months35133141010977129181211263299
to2140328101093182
1-year2257328101094773118164209240
follow‑up.2532328101092779102124176245275328381400
Repeat2967328101095098151199245276
stenting3278328101093669115167198220272325
with3638328101096891122174
everolimus‑DES2140342101094691137167218241262340391427456520566612
(EES)2781342101092671116162188
which29983421010968120142183235
is3261342101092258
classified3348342101094163108144181202230254301355
as3731342101094581
second‑generation2140356101093681121169219269297349394444488518561589610659708
DES28713561010960104148
was30423561010966109144
found3208356101092776125174225
to3455356101093078
be3556356101095196
statistically3675356101093666109214037010109305086116136176220241262304
superior2468370101093685136182211232282311
to2803370101093079
all290637010109436485
other3015370101094979128174203
modalities32423701010976125177220241261291311356392
(23).3658370101092570116138154
The2140384101094595140
RIBS2295384101094970119162
III247238410109224364
trial255138410109305980122143
(Restenosis2709384101092673118153183227276325360380415
Intrastent:3139384101092271100128171206236280330358377
Balloon3531384101094992113133182232282
Angioplasty21403981010955104154175224274296338373403447
Versus2605398101095091120156205239
Elective2862398101094464109150181201244288
Stenting)3167398101094572116166194214264314337
suggested35223981010935841341842282632140412101093176130
that2296412101093082126156
the2479412101093081128
use2633412101095288135
of2794412101095178
second‑generation2898412101093784126176228280310364411463510540585615637688740
and3664412101094496148
limus‑type2140426101092141115164198225254298349395
DES25494261010960104148
was27114261010966109143
associated2868426101094478113162202222264293337387
with3270426101096686115164
better3448426101095297126157201230
angiographic36924261010943922140440101095070118168197239289338358398
outcomes2552440101094997126165212286330365
although293144010109436392140189237287336
further3280440101092776104135184228257
studies3551440101093565113163183227262
with2140454101096585114162
larger231545410109216290138182210
sample2539454101093577150199219263
sizes281545410109355592135169
would29974541010966113161181230
be3240454101095095
required3348454101092972122169189217260310
(21).3671454101092568108126142
Nonetheless,22804681010961115170219253306356381430469508531
the2871468101093084133
debate30644681010953102158205238287
regarding3411468101093079134181214269293347402
whether21404821010966116161190239284313
to2470482101093078
use2565482101095084129
a27114821010944
DES27724821010960104148
eluting2937482101094566115144164213263
the3217482101093079124
same3358482101093579153198
or3573482101094979
a36694821010943
similar37294821010935562140496101097493112153181
type2333496101093072122166
of2511496101094973
drug2597496101095077125173
(homo‑DES2783496101092573120193240268328370413
approach)3208496101094392141169216258296344365
versus3585496101094385113147194227
a21405101010943
switch21965101010935100120149187234
to2444510101092976
a25335101010943
different259051010109506994122166194238286314
type2917510101092973123167
of3098510101094873
drug3185510101095077126175
(hetero‑DES3373510101092573117146189217264293353396440
approach)2140524101094391141169216258296344365
has2518524101094990124
continued.2655524101093985134161180228275318368385
The3053524101094493136
hypothesis3202524101094988138186214262305339358391
of3606524101094973
the3692524101093077121
switch21405381010935101122151189238
approach2392538101094393144173221264303352
benefit2758538101095196145190216238267
is3039538101092156
based3109538101095193128172223
on3346538101094998
the3458538101093079123
possibility35955381010951101135170189214055210109517191110139182
that2336552101092977119147
it2497552101092149
might2560552101097494142191219
overcome2792552101094990133161200247320364
drug3170552101095078127176
resistance3359552101092973107127160190232281320363
or3735552101094977
polymer‑related2140566101095098119159232276304327356399419460488530580
problems2733566101095078125174194238310344
(4).309056610109256688103
Furthermore,3206566101094389116147194238266338386414457473
the3692566101093077120
RIBS2140580101094971120163
III232758010109224365
trial241658010109305980123144
assessed2584580101094479114159195230275327
the2935580101093080125
impact3084580101092196147191232263
of3371580101095076
selecting3471580101093681103148189221241291342
a21405941010944
different220759410109517298127172202246296325
DES25565941010960104149
for2729594101092676105
the2858594101093079125
treatment3006594101093059104147176251296346375
of3405594101094975
ISR.3504594101092266113134
This3662594101094595116151
study2140608101093564111160202
showed2355608101093582130193236286
that,2654608101092977118146164
in2831608101092068
patients2912608101095093120140183231259294
with3219608101096585113161
DES33936081010958101144
ISR,3550608101092164109129
the3692608101092977120
use2140622101095084129
of2286622101094975
a23786221010943
different243862210109517197126171200244293322
DES27776221010960104148
yielded2942622101094263108129179224275
superior3234622101093584134180209230279308
clinical355862210109416181130151190234254
and2140636101094494146
angiographic2310636101094495146167217268298342393444465506
long‑term2840636101092272123174203233278308384
results3248636101093076112161182212249
compared35216361010941901672182622140650101093076129
with2294650101096890120171
those2490650101093182132169215
seen2730650101093783130182
with2937650101096889120171
other3133650101095081132178208
therapeutic3366650101093182128159203256303354384405447
modalities21406641010975124175218238259288308353388
(21).2545664101092670111130146
However,22806781010959108173217260303332346
a26436781010943
potential27026781010951101130174224252272315335
drawback3054678101095179122187238281321362
of3433678101094975
DES35246781010960104148
implantation36896781010921952140692101095172115164192236264285333383
is2537692101092156
that2607692101093079122150
another2772692101094392141170219264293
layer3079692101092164104148177
of3271692101094975
a33606921010943
stent3418692101093565109158187
is3619692101092156
implanted,36896921010921952140706101095071113161188231281299
which24527061010965114134172220
can2686706101093982130
lead2829706101092165107156
to2998706101093077
ensuing3088706101094593127174194242291
therapeutic3392706101092977121150192241285334362382420
challenges2140720101094089132153173218267317362397
in2554720101092170
the2642720101092979123
event2783720101094587131180209
of3009720101095075
ISR3102720101092165112
recurrence3231720101092974114163192221265315355399
(22).3647720101092569115137154
Drug‑Coated21407450014782126195264303378444506548610681
Baloon28487450014769131163231300369
(DCB)32447450014736117189258292
DCB22807621010960113161
offers2457762101095076106151181218
the2691762101093080125
advantage2832762101094495139183233262306357402
of3251762101094975
avoiding3343762101094385134155206228277328
the3687762101093080126
implantation2140776101092197149172216267297341372393444495
of2661776101094976
an2763776101094495
additional2884776101094496148169200221272323367389
metallic32997761010976122153198220241263304
layer3629776101092166108153183
when3940621010967118164215
treating418162101093060105149179201251303
ISR,450962101092267115137
and467262101094394146
is484362101092258
recommended492662101093076118167243319365416468514567
by551862101095294
the394076101093081128
European409476101094595126176229277321373
Society449376101094596139160207238284
of480476101095077
Cardiology490776101095499129181203254277328380425
guidelines535876101095110212417622339409010109214393139175
as414190101094480
a4246901010944
treatment431690101093060105149179255301352382
option4724901010949102132153204255
(Class50049010109267798142178214
I,524490101092241
Level531190101094388132177199
of553690101095076
Evidence:3940104101094487109160206256297342360
A)4319104101095580
(24).4418104101092671115139156
DCB40801181010960113162
has4261118101095093129
a44091181010943
potential44711181010951102132177227257278321343
role4833118101092979101146
in4999118101092171
the5089118101092979125
treatment5233118101093060105149178253299350379
of3940132101094975
DES‑ISR40311321010960104149179202246294
by4341132101095193
avoiding4449132101094385134155206227277327
the4792132101092979124
placement4932132101095173116156201276321371400
of5348132101094976
another54391321010944931433940146101092978122151
layer4106146101092164104147176
of4297146101094975
the4386146101093078123
stent4524146101093565108157186
and4725146101094391141
providing4881146101095180128170191241261310359
favourable52551461010926691101582072352783283940160101092167
results.4023160101092975110160181211248267
DCB43061601010960113162
can4484160101094084134
be4634160101095198
particularly4748160101095195125157178219268290333363384427
suitable5191160101093685106137181232254300
for5507160101092676106
clinical394017410109406182131152193237258
situations421317410109365787136179208229279329364
where45931741010966116161191236
it4845174101092150
is4911174101092156
not4983174101095099129
applicable5128174101094394145167188228272323345390
to5534174101092978
add3940188101094495147
another4113188101094394144174224270300
layer4439188101092165107152182
of4647188101094976
the4749188101093080126
stent4901188101093667112162192
(i.e.,511918810109264666111130150
multiple52941881010976125147177199250272318
previous3940202101095181127170192242292328
stent4293202101093667112162192
layers,4510202101092165106151181218237
the4773202101093080126
presence4924202101095181127163208259300344
of5294202101094976
a53952021010944
major546420210109751193940216101092272102
side4068216101093657109155
branch)4248216101095282126177218268292
or4565216101095080
for4671216101092676107
bleeding4803216101095274120167219240291342
events,5170216101094689134185215252271
and5467216101094494146
can3940230101094084133
be4089230101095196
particularly4201230101095194123156176216265287329359380422
suited4639230101093584105135179230
to4885230101092978
clinical497823010109406182131152192236257
situations525123010109355585134177206227276326361
where39402441010966117163193238
the4202244101092979125
mechanism43512441010975121162212256306327363438
of4812244101095076
ISR4912244101092266114
is5050244101092157
stent5130244101093667112162191
maldeployment534524410109751191401922373940258101095173123165241287338367
(4,432625810109267088
5,4433258101094664
25).4516258101094692117134
DCB40802721010959111159
was42542721010966109143
ranked4413272101092972121163206257
as4685272101094378
the4778272101093079124
second4917272101093580121168218268
most52012721010974123158188
effective5404272101094571100145185394028610109295093137
treatment4092286101092958103145174248293343371
for4479286101092675104
ISR4598286101092165112
based4725286101095194129174225
on4965286101094999
meta‑analyses50792861010974119149192221263313355376418453498533
conducted3940300101094089140191241281314358410
by4367300101095193
Siontis4477300101094465115165195216252
et4745300101094576
al4837300101094465
(23).4919300101092570117140157
No50923001010960110
significant5219300101093556107157178205229270314364393
difference394031410109517299128174204249300341385
in4342314101092171
the4430314101093080125
risk457231410109305187129
of4718314101094976
all‑cause481131410109436586115158202252287333
death,5161314101095196140170220239
myocardial541631410109751171663940328101094085115166187231253
infarction,421832810109217298143173213245267317367387
or4630328101095080
target4736328101092974104155200231
lesion4993328101092167103124174225
thrombosis5244328101093080110159235287338394034210109365792
between4053342101095298128197242288338
treatments4413342101092959104148178253299349379416
of4850342101094976
DCB49473421010960113161
and5129342101094494145
DES52953421010960105151
was54673421010966110145
observed39403561010949101136182212258302354
(8.7%431035610109257090135206
vs.453235610109437998
7.5%;4646356101094656105174193
HR:48553561010958107126
1.13;4997356101094661102142159
95%5172356101094691161
CI:534935610109527291
0.655456356101094665111156
to3940370101093079
1.96).4045370101094762107155179196
However,42673701010959110176222265310340356
DCB46483701010961114163
angioplasty4837370101094494145167217270292336372403449
showed5311370101093687137204249301
a39403841010943
slightly399838410109355676125174203223265
better4278384101095196126157201230
performance4523384101095095124153202231305348397436480
in5018384101092170
BMS‑ISR51033841010948119162191214257304
compared54223841010940881623940398101095195125170222
with4181398101096788118168
DES‑ISR43683981010960105150180204248297
in4684398101092171
some4774398101093585161207
studies5000398101093667116168189235270
(4,529039810109256987
22).5396398101094793116134
Furthermore,4080412101094492121154204250280355405435481499
in4595412101092171
DES‑ISR,46834121010960105150180203248296317
there5016412101093080126156201
was52344121010966110145
a53964121010943
borderline545541210109521021323940426101095196126148169219265
numerical42294261010950100175221251272313357379
trend4632426101092959104155206
toward4862426101093079145189218269
a51554261010944
decreased5223426101095096138167212256292337389
risk394044010109295085126
after4081440101094368101144173
DCB42694401010960112159
angioplasty4443440101094392141162211261283325360390434
compared4892440101094087161212255284328379
with5286440101096586115164
DES54654401010959103147
implantation3940454101092195145167210259288332361381430480
(9.5%443545410109266985132201
vs.465245410109437897
13.3%;4764454101094686104152221239
HR:50194541010958106125
0.69;5159454101094664110155173
95%5347454101094691160
CI:552245410109527291
0.473940468101094665111154
to4113468101093079
1.00)4211468101094661108156181
(22,4411468101092570116135
26).4565468101094691115132
In4080482101092272
recent4175482101092974116160211240
years,4438482101094287131160197216
sirolimus467748210109365786136158179254304339
DCBs50394821010960114162197
have5259482101095094136180
also5462482101094465101151
been3940496101095196142192
developed,4147496101095196138182204253304350401420
and4582496101094393143
a47414961010943
comparison4799496101094088163214258287308343392442
of5257496101094975
a53474961010943
novel5406496101094999141185206
SCB3940510101094497145
with4102510101096688118168
a42865101010943
crystalline4346510101094070115151182227248269290340386
coating4749510101094089133163184234284
showed5050510101093686136202246298
similar5365510101093656132153174218247
angiographic3940524101094494145167217269299343395446468509
outcomes44745241010950101131171220296343379
in4879524101092171
the4976524101093080126
treatment5128524101093060106150179255302352382
of5536524101095076
both39405381010951102132182
coronary4141538101094089119168219262292338
de4498538101095096
novo46135381010950100143192
disease4824538101095172107153197232278
and5121538101094494145
ISR5285538101092266114
compared54185381010941891653940552101095195125170222
with4181552101096788118168
a43685521010944
clinically443155210109406182132154194239260281324
proven4774552101095282131174218269
PCB50625521010948100149
(27,5230552101092570114124
28).5373552101094792117134
Plain3940577001476797159190259
Old42265770014785117188
Balloon44415770014769131162193262331400
Angioplasty48685770014776145215246314385417478528572635
(POBA)39405910014736102187258333368
POBA40806081010948110160214
is4314608101092156
one43906081010949100146
of4555608101095076
the4651608101093079125
initial479660810109217192122143187208
treatments5024608101093059104148178253299349379416
that5459608101093080123153
has3940622101095094129
been4092622101095197143194
used4308622101095086131183
in4514622101092171
patients4608622101095195125146191242271308
with4939622101096688118168
ISR.5129622101092266114136
The5287622101094596142
procedure54516221010952821313940636101094085137186216261
consistently4221636101094089139175196231262307357387408451
shows4692636101093585135201237
satisfactory4948636101093681110131167194239279312361391436
acute5404636101094384133164208
results3940650101092975111160181211248
and4210650101094393145
a43766501010944
very4441650101094388118163
low4626650101092171137
occurrence4785650101094990130180209240285335376421
of5227650101095076
complications.53256501010940891642162382593940664101094085114135185236271291
The4249664101094596142
use4410664101094985131
of4560664101094976
high‑pressure4654664101095072122172202254284330365401450480525
balloons5198664101095196117138188239289325
in5541664101092172
ISR3940678101092266114
is4073678101092157
most41496781010975125161191
important4360678101092196147198228260305355384
for4764678101092676106
mechanical48896781010975121162212256306327368412433
causes.5341678101094185135170216252271
It3940692101092252
can4009692101094085135
be4161692101095198
used4276692101095085131183
for4476692101092777107
stent4600692101093667111162191
underexpansion48096921010949100151197227272315366411461496517567618
with5444692101096688118168
noncompliant39407062010950100150191240316367389410454504533
balloons4495706201095196117138188239289325
with4842706201096687118168
a50317062010944
high5097706201095071121172
pressure5290706201095282127163198248277323
of3940720101094975
approximately4031720101094393144174223263285359402431475497539
404586720101094592
atm.4694720101094372146165
However,48757201010958108173217260304333348
one5238720101094999144
of5398720101094975
the5488720101093079124
limitations3940734101092143118140170215245266316367403
of4369734101094976
POBA44717341010948111161216
is4713734101092157
that4795734101093081125154
the4975734101093080127
acute5127734101094485135166211
gain5363734101095195116167
is5555734101092257
short‑lived,3940748101093686136166198224247268312356408427
and4391748101094393144
subacute4559748101093585136180221271301346
tissue492874810109305187122172217
re‑intrusion5169748101092974105127177206236286322343393443
back3940762101095195136178
to4141762101093079
the4243762101093079125
lumen4391762101092171146192242
tends4656762101093075125177212
to4891762101093079
occur4993762101094990130180209
within5225762101096688118168189239
minutes548776210109759639407761010950100130175210
of4167776101094976
the4260776101092979125
last4402776101092164100131
balloon4549776101095296117139189239290
inflation.485577610109217198122165195216266316336
The5207776101094596142
proce-5365776101095282131173217247