990
12756558026012657110166
www.iakardiologie.cz3408043010765133201214233274312354380428447495515563613632675690730769
/26598043010732
Interv273680430107196793136162206
Akut2962804301075391139167
Kardiol.3149804301074587114162180228248264
2023;22(3):122-1283433804301074487128172186230274295338359373411448492517556593636
/41148043010731
INTERVENČNÍ4191804301071978123168215263308366420478499
A47128043010752
AKUTNÍ4786804301075399158203263284
KARDIOLOGIE50918043010745103150211232295337397456477521
PŘEHLEDOVÉ3620207012660124182256312369444520587645
ČLÁNKY4287207012660115187259327395
/4703207012633
REVIEW4756207012662121191224282376
ARTICLES5153207012668131191224287342399458
Treatment39453650106306698140168221253294327
options428736501063974106123164206238
of454136501063869
in‑stent46263650106155684114147179220253
restenosis:489436501063466100133165206247280297329345
mini525336501065270111128
review539736501063365105122154215
pansion34062101095399151188210262315
in68262101092174
balloon‑resistant78362101095298121143195248301331364411448470508540586638669
lesions.147962101092270107129181234271292
It179862101092253
has187862101095297135
been340761010953101149202
effective57176101094775107154198232254300347
for94776101092779110
PCI1087761010949104126
of124276101095179
complex135076101094293171225248296341
lesions,172076101092270107130182235272292
including34090101092172114135186238260311362
stent72990101093667113164194
restenosis,94990101093076112144189241292328349386405
calcified138190101094085107149170198222268321
lesions,172890101092268105126177229265284
and340104101094393143
chronic499104101094089118167217238278
total793104101092978107151172
occlusion.981104101094990129150199234255304354373
It1370104101092151
is1436104101092156
both15081041010951101130180
safe1703104101093680106151
and1869104101094493144
effective340118101094571101145186218239282326
for681118101092675105
plaque801118101095173116166215260
modification.10771181010974124175195222245285329358379428478497
Ichimoto1589118101092162111132206255285333
et1938118101094474
al340132101094363
conducted418132101094088137187235275306350400
a8341321010942
clinical89113210109406081129150189232253
study1159132101093565114164206
to1380132101092977
investigate1472132101092169110154189219239288331359403
the1890132101092978123
outcomes3401461010950100130170219295341377
after742146101094471104149179
treatment946146101093060105149179254300351381
with1352146101096788119169
ELCA1546146101094587138194
for1766146101092676106
ISR1898146101092266114
of340160101094976
des.437160101095197133152
The611160101094495141
study774160101093566116167210
showed1006160101093585135201246298
that1325160101093080124153
acute1500160101094384134164208
luminal1730160101092171146167217261282
gain340174101095094115165
was5271741010967111146
greater695174101095180126169199244273
in991174101092171
PCI10841741010948100121
with1228174101096688118168
the1418174101093080125
ELCA1566174101094486136193
group1781174101095180130180231
than340188101093182127179
without546188101096891122174226278309
ELCA.882188101094589141200222
There1131188101094699146177224
was13821881010968113150
slightly155918810109375981133185216238283
less1869188101092269106143
TLR340202101094589137
in503202101092171
patients600202101095196126147193244273310
with936202101096788119169
ELCA1131202101094487137194
for1351202101092676106
ISR1483202101092266115
compared1623202101094190166218262292337389
to340216101092978
those433216101092978128163207
without,656216101096586116165214263293312
and983216101094392143
there1141216101092978123153197
was13532161010966109144
no1512216101095099
significant1626216101093556105155175201225265308357386
difference34023010109517299129174204249300341385
in746230101092171
cardiovascular838230101094185115166187237280323359400450471515544
events1403230101094689133184213250
between1674230101095298128197242288339
patients340244101095195125146192242272309
with668244101096688118168
and855244101094393145
without1019244101096688118168218268298
ELCA1336244101094487137194
(48).1549244101092569117141158
Rotational3402690014768136179241283314382451513544
Atherectomy9112690014776117186248292354410455522625683
(RA)16212690014736104183218
RA4802861010949106
is612286101092157
an695286101094494
atheroablative815286101094474124171201251296347370414444465509554
technology1395286101093075117168218269291341393437
that1858286101093080124154
enables340300101094699144198221269306
PCI6733001010949104126
for826300101092779111
complex,964300101094192170224247295339361
calcified1352300101094188110153175203228276330
coronary1709300101094192123175228273340314101093076
lesions.442314101092167104125175226262282
The750314101094597143
principal919314101095182104154196217269313335
indication1280314101092172124145186231261282333384
for1690314101092677107
RA18233141010949106
is1955314101092257
a3403281010943
modification4093281010975125177198225249290334364385435485
of920328101094976
severely1021328101093682125170200245267310
calcified1357328101094084106147168195218264316
de1698328101095197
novo18203281010950100143192
coronary340342101094190120170221266296342
stenoses708342101093567112163213250296332
which10663421010967118139181231
are1323342101094474119
unlikely14683421010950101123144187232254298
to1791342101093080
expand1897342101094589340356101095195145196
adequately552356101094394139191240284313358379422
with990356101096688118167
balloon1173356101095195116137187237288
angioplasty1477356101094393143164214265287330366396441
to1934356101093079
allow34037010109436586136202
for563370101092676106
complete690370101094089165216238284314359
stent1070370101093667111162191
expansion1282370101094588140184234270291341391
(49).1694370101092670115139156
The1871370101094496141
randomised340384101093075126178229306328364411464
PREPARE‑CALC830384101094997143192243293339367424482525576
Trial143338410109457092137159
compared1618384101094191168220265295342394
high‑speed340398101095072123174204240292339386438
RA8043981010949107
and937398101094494146
modified11093981010976127179201228252298351
balloons1486398101095196118140190241292328
(MB)1840398101092698148172
before3404121010953101130182213261
DES6294121010962109156
implantation8134121010922100154177223275306352384406458511
in1352412101092274
severely1455412101093684129176207255278323
calcified180641210109428811115417634042610109265096148
coronary508426101094089119168219262292337
lesions.865426101092267103124174225260280
After1165426101095581114159188
complete1373426101094189165217239284315359
clinical175242610109416283133154195239260
follow‑up34044010109267596116165230258308358
over713440101094991134163
98914401010946
months,9524401010974123172201250284303
the1270440101092978123
overall1408440101094991134163206227248
mortality16714401010974122152183227247268297341
was3404541010965107142
2%4974541010945114
in626454101092069
both710454101095099128176
groups901454101094978126174224259
(P1174454101092572
=12604541010953
1.00),1328454101094559104151174191
spontaneous1533454101093585134183211254303347396445479
myocardial3404681010975117166207251281332353396418
infarction78346810109217198142172212244265315365
occurred1174468101094991130180210240285337
in1536468101092171
216324681010947
patients1704468101095195125146192242272308
in340482101092171
the427482101093080126
MB5694821010972121
group707482101095079129179230
and954482101094393144
in1114482101092171
none1202482101094999150196
in1414482101092171
the1501482101093080125
RA16424821010949106
group,1764482101095080129179231249
and340496101094394145
TLR502496101094588136
was6554961010967111146
twice818496101093099120161205
as1040496101094479
high1136496101095072122172
in1325496101092171
the1413496101093080126
MB15564961010972122
group.1695496101095080129179231249
It1961496101092152
showed340510101093584133197241292
that647510101092978121149
there811510101093078123152196
was10225101010966108143
no1180510101094998
significant1293510101093556105154174200223263306355384
difference169251010109507096125170199243292340524101094085
in444524101092171
clinical53452410109406183133154194239260
outcomes8135241010949100130170218294340376
at1208524101094373
913005241010946
months13655241010975125175205255290
between1674524101095298128197242288338
the340538101093080126
MB4855381010972121
and625538101094494145
RA7895381010949106
groups914538101095080130180231267
(50).1200538101092570116140157
Coronary3405630014771137181249318379422486
Artery8545630014776119164226269333
Bypass12155630014769130201263314363
Graft16065630014780124185224270
(CABG)3405770014736104183251332366
In480594101092273
patients579594101095398128150197248278316
with921594101096890121172
symptomatic1119594101093781159212242293370414445467508
recurrent1653594101093077119170200231277329359
diffuse340608101095173100130181217263
ISR629608101092166115
with769608101096789120170
an965608101094394
indication1085608101092171123145186230260282332383
for1494608101092676107
revascularisation,162660810109307611916420024129131335734062210109305391137169191243296317
CABG6876221010954113164225
can942622101094188140
be11126221010953102
advantageous1244622101094498144190243274320373421474527564
over1838622101095196143175
repeat340636101092975126173216246
PCI6106361010947100121
to755636101093079
reduce857636101093075127176217262
recurrent1142636101093075117166196226271322351
events1517636101094588133183213250
(Level1790636101092668113156201223
of340650101095179
recommendation447650101093178121172251329377429483528560582634687
2a)1162650101094893118
(18).1309650101092670114140158
In1495650101092275
a15986501010945
previous1671650101095384131177200252304342
study,340664101093769121174219235
patients602664101095298129151199251282320
who9496641010968121173
underwent11496641010951103156203235306353405436
CABG16126641010954113163224
had1863664101095196150
a3406781010943
significantly398678101093556105155175201225264308357386406448
lower862678101092170134178208
incidence1085678101092170110130181225275315359
of1459678101094975
target1549678101092973102151196226
vessel1790678101094386121156201223
revascularisation340692101092973116159194234282303346375396431474503523572622
(8%)977692101092669140162
and1155692101094392142
MACE13126921010972127176219
(23%)1546692101092569115184206
before1768692101095096122171200244
PCI2140621010948100120
(51,227662101092670112126
52).241862101094689113130
Reports256462101094893144195224257293
on287362101094999
the298862101093079125
incidence312862101092171111132183228278319363
of350762101094975
CABG3598621010952108156214
due2140761010951101148
to231476101093079
restenosis241976101093076112144189240291327348384
after282976101094471104150180
BMS3035761010949123168
or322976101095080
DES3335761010960106152
and351376101094394146
the368576101093081127
clinical21409010109406283133154194239260
outcomes2419901010950100130170218294340376
are281490101094373118
scarce295190101093677121151191235
in320590101092171
the329690101092979125
literature.34409010109214273117147191221271300346364
Adjunctive21401150014776145178246315370415446507568
Medical27351150014799163234265319381412
Therapy31751150014763132195239300370430
Systemic2280132101094481114143184257275313
treatments260513210109295698139166238281328355389
have3006132101094989129171
targeted318813210109297198145188216258307
different350613210109506993120163190232280306
mechanisms21401461010976120160209251300319353427461
that2624146101093078120149
have2795146101095092133176
been2993146101095297142191
identified3206146101092171115164192212237260304354
as3582146101094478
potential368214610109521012140160101093072120148167208227
factors2379160101092769107137184212246
in2637160101092169
the2718160101093078121
development2851160101095194135178197245295368412460487
of3350160101094974
restenosis.3436160101092972106135177225273307325359376
Platelets2140174101094765106133175194237265299
and2450174101094390138
thrombi2600174101092976103149222270289
were29011741010965107134176
first308917410109264774108136
attributed3236174101094370100126146194241268310359
to3607174101092975
the3694174101092976119
cascade2140188101094184119159202253298
of2460188101095076
events2559188101094588131181209245
leading2827188101092166109160180229279
to3129188101093078
neointimal3230188101095095145165215243263338380401
proliferation.3653188101095281130214020210109214166111139182210230278328345
However,25082021010959108173216258301330343
antiplatelets2874202101094392120140190210253281324345389418454
and3350202101094493143
anticoagulants35152021010944921211401792272702140216101095098118160208236271
did2429216101095170120
not2567216101095098126
reduce2711216101093073123171210253
neointimal2982216101095094143163211239258331373393
hyperplasia3393216101095089140184213263283325358378419
and2140230101094392141
restenosis2297230101093073107136179228276310329363
rates267623010109297199142176
(53).2868230101092668111132147
Sirolimus303123010109456491139159179252300334
or3381230101094977
cilostazol347423010109406079127161190233271318338
may21402441010974115153
be2304244101095194
of2409244101094973
benefit2493244101095194141184208230257
in2762244101092067
patients2841244101095091118137179227253287
who31402441010965112159
had3311244101094989138
restenosis3460244101092971104132174222268301320352
more21402581010975123152195
than2348258101092977119168
twice2528258101093097117156198
in2739258101092169
the2821258101093078122
same2955258101093679152196
area.3164258101094371114156174
They3350258101094594138179
may35412581010975117157
reduce37112581010929722140272101095098136178
the2331272101092977120
amount24632721010943116164212259287
of2762272101094973
restenosis2848272101092972105134176224272306324358
tissue321827210109294882115162205
that3436272101092977118145
builds3594272101095098117136185219
up.21402861010951102119
The2282286101094697143
double‑blind,24482861010952102152203224270300352373393443495513
randomised,2984286101093074124175225301322357402454472
placebo­3479286101095374117157202253304333
‑controlled2140300101092869116165193221269289309353403
Oral2565300101096291134153
Sirolimus274030010109456492140160179253301335
to3097300101093077
Inhibit3196300101092271119139188208237
Recurrent3455300101094893132181209237281330357
In‑stent214031410109227097132161204253280
Stenosis2438314101094471114163211245264298
(OSIRIS)2753314101092685127146193214256280
trial305031410109305878120139
showed3207314101093684132196239289
that3514314101093078120148
restenosis36793141010930731072140328101092972119167200219252
can2403328101094082129
be2544328101095194
reduced2650328101092972121168206248297
by2959328101095190
short‑term3061328101093583130158188211239281309382
treatment3454328101093057100141168240283331358
with2140342101096686114162
sirolimus.231534210109365582130150169243290324342
There2670342101094494137166209
was28913421010967109142
a30463421010943
significant3102342101093655103152171196218257299347375
correlation34903421010940871151431872072482762952140356101094998
between2258356101095195124191234278327
sirolimus260535610109355482130150169243290324
blood2949356101095171120168218
concentration3187356101094087136175218266294322364392411459508
on3714356101095099
the2140370101093079123
day2285370101095193133
of2441370101094974
the2537370101093079123
procedure2683370101095180128168211261310338382
with3087370101096686115164
the3273370101093078123
late341837010109216392135
lumen3575370101092170144188237
loss2140384101092169103137
at2293384101094371
follow‑up237938410109277595114162227253303353
(P2747384101092671
<28343841010953
0.001)2903384101094663108154195213
(54).3131384101092668113135151
Current21404090014771135175216276343383
Guidelines25454090014780147176244305334363429490538
The2280426101094493137
20182429426101094689129169
ESC/EACTS2610426101094487137168210265313358401
guidelines3023426101095097116165209228247295338372
for3407426101092674102
myocardial352142610109741131601992412682140440101095171113133
revascularisation2295440101093074116158192232280300343371391425468496516564614
recommend2931440101093073114161236310354403454
either341044010109466898149195225
DES36614401010960106152
or2140454101094979
DCB22374541010960113161
for2415454101092777107
both25394541010951102132182
BMS‑ISR27384541010949121166196219264312
and3067454101094393145
DES‑ISR32294541010960105150180204248296
(Class354245410109267798141177212
I,3772454101092141
Level2140468101094388131176198
of2364468101094976
Evidence2466468101094487109160206257298343
A).283446810109568198
Intracoronary2958468101092172101131175216265295345396439469515
imaging3498468101092297141192213263314
such2140482101093583122170
as2325482101094277
IVUS2416482101092170128170
and/or2601482101094291140171215244
OCT28604821010960112158
should3032482101093584132181201251
be3297482101095095
considered3406482101094087136170190240284312356406
to2140496101092977
determine2233496101095094124168197271292341386
the2634496101092978123
most27724961010974123158188
appropriate2975496101094393144173222272302322365394438
procedure3428496101095079128168212263311340384
prior2140510101095181103153183
to2342510101093079
revascularisation2440510101092974118162197238288309353382404440484514535585635
(24).3094510101092671115139156
Different2280524101096285113144192223271323354
guidelines26635241010952104126180227251273325373411
by3102524101095397
ACC/AHA/SCAI32275241010957110162196249310368403449504563585
from2140538101092657106182
20212348538101094691136178
propose2551538101095282131183234270316
DES28925381010960105150
implantation3068538101092196147169213263293337367388438489
as3582538101094379
the3687538101092979125
leading2140552101092166110161182231282
revascularisation2437552101093074117161196237286307350379401436480509530580630
method30825521010975120151200250301
if3399552101092147
anatomic3462552101094393136165214289310350
factors2140566101092671111144193223259
are2425566101094373118
appropriate,2568566101094495147177226278308330373403448466
and3059566101094494145
the3230566101092979125
patient3381566101095195125146191242271
can3678566101094084134
comply2140580101094088163214235278
with2433580101096687117166
and2615580101094392143
tolerate277458010109297899144174217246291
antiplatelet3080580101094393122142193215258287331352398428
therapy3523580101093079124154197248289
(Class214059410109267697140176211
I,2367594101092241
Level2424594101094388131175197
of2637594101094976
Evidence2729594101094487109160205255296341
A).308659410109558097
Additionally,31995941010955105156177207228278328372393414457472
the3687594101093080125
guidelines21406081010951102123176222245266317364401
suggest2567608101093686138190236273305
the2898608101093081128
use3052608101095086133
of3211608101095078
vascular3315608101094489125167217239284314
brachytherapy36556081010952831282140622101094090132165215260290334386428
for2587622101092676106
patients2712622101095195125146192242272308
with3039622101096788119169
an3226622101094494
artery3339622101094373106150180226
that3584622101093080123153
is3756622101092156
unfavourable2140636101094998124167208256305334377428449494
to2649636101092977
receive2741636101092974114158178221265
another3021636101094392141170219264293
DES33296361010959103147
and3491636101094392142
who36496361010965115163
are2140650101094373118
not22846501010950100130
good24396501010951101151203
candidates2668650101094084135186207259303332377413
for3106650101092777107
bypass3238650101095294146190226262
surgery3525650101093685115166211241287
(Class214066410109267697141176212
223716641010946
b,2436664101095169
Level2524664101094388131175197
of2741664101094976
Evidence2836664101094487109160206256297341
B‑NR)3196664101094979141190215
(18).3430664101092567109134151
Moreover,22806781010972123153198249291336366381
in2682678101092171
patients2774678101095196125146192242272309
with3104678101096688118168
recurrent3293678101093075116166196226271321351
episodes36656781010945971182140692101093688142189226
of2393692101095078
diffuse2498692101095174101132184221269
ISR2793692101092268118
in2937692101092274
large303769210109226798150197
vessels,3261692101094490127164211234271291
multivessel35796921010977128150181203394062101094591129166214237
disease,420462101095274112159205242290309
or454062101095183
in465062101092173
the475162101093082130
presence490862101095384131169217269312358
of529362101095179
other539962101095182134182213
complex394076101094089164215237282325
lesions428176101092167102123173223259
such455676101093584125175
as474776101094378
chronic484176101094090119169219240280
total513776101093079109153174
occlusions,5327761010949911301512002362573940901010949100135154
both4110901010951101131181
European430790101094492122171222268312362
and468590101094393144
American4845901010955130175205226267311361
guidelines522290101095099120171217239259309355390
suggest3940104101093685136187232268299
performing4258104101095298128157207237313334384435
CABG47121041010952109158216
over4947104101095092137167
PCI51331041010948100121
(18,5273104101092668110130
24).5422104101094690114131
The4080118101094699147
20224254118101094794140188
EuroIntervention4469118101094696127179202254285332363411458510541563615667
publication51631181010953105159182204246292323345397450
„Management39401321010931104146195237286330403448496525
of4479132101094874
in‑stent456713210109216997132162205254282
restenosis“4863132101092973107137180229277311331365396
proposes5273132101095179127177226261305340
an3940146101094394
ISR4055146101092266114
treatment4191146101093060107152184261308360392
algorithm.4608146101094467120171203227259310387409
This5042146101094598121158
algorithm5225146101094467120172204227259311388
is3940160101092158
based4018160101095197134181235
primarily4273160101095182106182228259282305350
on46421601010950102
the4763160101093082129
type4912160101092976130178
of5110160101094977
stent5207160101093568114166198
used5424160101095087134188
in3940174101092173
the4033174101092981129
initial418117410109217396128151196219
procedure4420174101095183134177224277329360407
and4847174101094395148
the5015174101092981129
mechanical51631741010975123166218263315338380426450
issues394018810109215793143190226
of4185188101094976
ISR.4280188101092166115137
If4436188101092149
no45031881010950100
mechanical46221881010974120162213257308330371416438
issue507918810109215794143190
is5287188101092157
found,5363188101092676127178230250
or3940202101095081
IVI405120210109217498
is4179202101092158
unavailable,42662021010950102148192238261284330383407454475
the4770202101093082129
recommendation4928202101093077121171249326374426480525557580632684
is3940216101092159
to4029216101093081
focus4140216101092779123175213
on43832161010950103
routine4515216101093082135167191243291
predilatation4836216101095284132186210233279311358390413466519
of5384216101095079
ISR5493216101092268119
lesions3940230101092167104126177228265
such4223230101093686127178
as4420230101094379
POBA,45182301010947110160215237
RA,47742301010948106128
ELCA,4921230101094386137195217
IVL,5156230101092273118139
cutting,5313230101094091122155177228279300
and3940244101094395148
scoring4111244101093679129161184236289
balloons.4422244101095298121144196248300338359
When40802581010975126172223
mechanical43212581010974120162213257307329370415437
issues477725810109205793143189225
are5021258101094272118
present,5158258101095081126163209260290310
the5487258101092979125
operator39402721010949103151183229260311343
can4308272101094187138
decide4472272101095198141164217265
on47622721010950102
the4889272101093082129
best5044272101095199137169
approach5239272101094396150182233279322373
to3940286101093082
address4052286101094498153185233272310
the4392286101093083132
problem4553286101095385138192217265344
and4927286101094497151
how51082861010951104173
to5311286101093082
treat5423286101093062111157189
the3940300101093082129
lesion.4091300101092168106129181233254
DCBs43673001010959115165202
and4590300101094496149
DESs47603001010960107154190
are4972300101094375122
used5115300101095087135189
to5325300101093081
treat5427300101093062109154185
the3940314101093083132
lesion4102314101092170109132185238
in4370314101092275
the4475314101093083132
majority46373141010976122147199232256289337
of5004314101095079
cases.5113314101094188127175214236
When53793141010977131180233
the3940328101093082131
type4100328101093078132181
of4311328101094978
stent4419328101093669116169200
is4649328101092159
unknown47373281010950103148202254323376
and5142328101094497150
in5322328101092173
DES­54253281010960108155187
‑ISR,3940342101092854101151174
DES41443421010960108155
appears4329342101094497152200247278317
to4676342101093081
be47873421010952100
moderately49173421010976128182230263309341388412458
more54043421010976129161208
effective3940356101094574106153196230253299345
than4308356101092981127179
DCB45093561010960115165
(5).469735610109267298117
Conclusion39403810014771137206261292361411442510580
Restenosis4080398101094995131162207257307343364400
is4505398101092257
much45883981010975125166216
less4830398101092167103138
common4994398101094089165241291342
due53613981010951101147
to5533398101093079
technical3940412101093075116166216237278322344
breakthroughs4301412101095181126170212245295325374424475525561
in4879412101092171
stents4968412101093566111161191228
and5213412101094494145
drugs.5376412101095080130181217236
Nevertheless,39404261010959104147191221253303348370415451486505
ISR4461426101092165113
does45904261010950100145181
still478742610109356686107128
occur4931426101094990130179208
and5155426101094393144
remains5314426101093074149193214263298
a39404401010943
significant4009440101093657108158179206230271315365395
issue.442944010109225793142188207
Contrary46614401010953101152182211256285331
to5018440101092979
the5122440101093080126
lower5273440101092272138183213
incidence55124401010921713940454101094061113158209250294
of4259454101095076
ISR4360454101092266114
in4499454101092171
DES,45954541010960105151170
patients4790454101095195125146191242271308
with5123454101096688118168
DES‑ISR53164541010960105150180204248297
display3940468101095173109162184228271
worse42374681010967117148185232
clinical449546810109416384135157198243265
outcomes47864681010951102132173223299346383
than5195468101093081125176
those5398468101093081132168215
with3940482101096688118168
BMS‑ISR41274821010949122166196220264312
after4458482101094470103148178
revascularisation.4655482101092975118162197238288309353383404440484514535585635655
While40804961010976126147168213
DES43094961010960104149
and4474496101094392143
DCB46334961010960112160
appear4809496101094394145191234264
to5088496101093079
provide5182496101095181130172194245290
the5488496101092979124
most39405101010975125161192
benefit4150510101095298148194221245275
for4444510101092676106
ISR,4569510101092166114135
the4723510101092979125
optimal48675101010949101131152227271292
strategy517851010109366796140170215266310
for5506510101092776106
managing39405241010975118168211261282332382
ISR4338524101092165113
must44675241010974124159190
be4672524101095197
determined4785524101095096126170200275296346391443
on52435241010950100
a53585241010944
case­5417524101094084120165195
‑by‑case3940538101092779120148190233267312
basis.4267538101095194129149184203
The4485538101094494139
underlying4639538101094998148193222243285306355405
mechanisms50595381010974119160208251300321355429464
of5538538101094974
the3940552101092978123
lesion,4079552101092065100121170219238
patient4332552101095094123143188237266
profile,4613552101095180129155178198243261
and4889552101094392143
prior5047552101095080101150179
treatment5241552101093058103146174248293343372
characteristics3940566101094090134163207248280325355377412443464505542
should4507566101093686136186208259
always4791566101094465132176217253
be5069566101095298
considered5192566101094189140175196248293323369420
before3940580101095197125174204250
deciding4207580101095196138159210231281332
on45575801010949100
ISR4674580101092166114
therapy.4805580101093080126156200251293308
Intravascular5131580101092171101130174217261296337387408452482
imaging39405941010922100146199222274328
aids4300594101094567121159
in4491594101092274
refining4597594101093078107132185208260314
clinical494359410109416487139162205251274
decision­52495941010953101144167204227279332363
‑making39406081010928104148190213263314
strategies427960810109356696140169214266287332368
through4672608101093080110159209260310
a50076081010944
more50766081010975125155200
detailed5301608101095197127171193214260311
anatomical3940622101094394137167216291313353397419
assessment4378622101094379115160196232307353403433
of4830622101094976
lesions.4925622101092167103124174224260279
Further4080636101094595127161213261293
research4404636101093077115163209240282335
is4769636101092259
needed4859636101095199148202250304
to5194636101093082
identify5306636101092275123176207230258307
other3940650101095081133180211
possible41776501010952104141178199252275322
clinical452565010109426485137159201246268
and4820650101094495148
anatomical4995650101094495140171221299321362408430
predispositions54526501010952831293940664101095070105155204239259288308357406440
and4395664101094392142
alternative455266410109426392136164214256285305348391
therapies4958664101092978122151194244265309344
that5317664101092978120149
can5481664101094083131
help3940678101095096118169
improve4134678101092196147177227270314
selection4473678101093682103149191223244294344
and4842678101094394145
tailor501267810109307495116166196
treatment5233678101093060105149178253299350379
in3940692101092171
each4030692101094589130180
individual4229692101092171122143187209260310353375
patient.4623692101095195125146192242272291
REFERENCES3417160012357112167220281336407470524579
1.34073200853648
Shlofmitz4057321083327086124143202217240270
E,69273210833346
Iantorno7557321083144785106143165203242
M,101473210835467
Waksman109873210835889119148206238276
R.139173210833550
Restenosis14577321083367198121155193231258272299
of177273210833857
Drug­184673210834567105144166
‑Eluting3407421083215570107130145183222
Stents:5757421083325387124146173186
A774742108341
New82774210834580131
Classification9717421083405587113140154172189221254275290328367
System13507421083336289112146204
Based15677421083356894129168
on174874210833776
Disease1837742108345608612115334075210832661
Mechanism41675210835489122160192230245271329
to75975210832259
Guide8327521083448297136171
Treatment10177521083335084116138196231269291
and132275210833270109
State‑of‑The‑Art14457521083335487108142165205224245275314349372414435460
Review.1919752108335703407622083324782133144
Circ4997622083405677108
Cardiovasc6227622083407394132147185217250277309
Interv.9467622083155375108129164174
2019;12(8):1-8.113676220833468100130143173203220254272284313332368381
2.34077200853652
Pleva4137721083365186119152
L,58677210833246
Kukla65377210833573103120153
P,82777210833540
Hlinomaz8887721083456076114153212245275
O.118477210834759
Treatment12647721083335185118140199234273295
of158077210833757
coronary16587721083326991129168201222257
in­19367721083155376
‑stent21407321083215074110150173
restenosis:23377321083215785110145185225253269297310
A2672732108342
systematic27387321083276190114150210244267283317
review.30797321083225791108144198210
J3313732108325
Geriatr336273210834582105122155178201
Cardiol.35877321083417698138155194211225
2018;15(2):173-84.214074210833468100131143173203221255273285315344378400436472485
3.214075200853753
Buccheri221875210833676110142182219242258
D,250175210834759
Piraino25857521083365274109126166207
D,281975210834659
Andolina290475210834383125166184200241276
G,320675210834560
et329375210833559
al.33797521083325064
Understanding34707521083458512716418821724227831821407621083385493133
and229476210833271111
managing242776210835790129162202218257296
in‑stent27457621083155477104128163202224
restenosis:29917621083215583107142180219247263289303
A3315762108341
review33787621083215689105141193
of359376210833757
clinical3672762108331476310211721407721083326683
data,22457721083397295130144
from24117721083194281141
pathogenesis25747721083407497137177218254294330358374402
to299877210832260
treatment.30817721083224580113136196233272295310
J3413772108325
Thorac,346077210833374114137171205219
DiS.37017721083466397111
2016;8(10):E1150-62.394073210833469101133146182202234266286298332364393424458483521555568
4.394074200853651
Her400574220834479100
AY,41197422083417281
Shin42137422083337186124
ES.43517422083326679
Current44447422083407798119154192213
management467174220835790128160199234292327365387
of507174220833857
in‑stent51427422083145275102125159197218
restenosis.537474220832155821051391772153940752208326416781
Korean40367522083357294128160198
Circ42517522083405881114
J.438475220832539
2018;48(5):337-49.444375220833470104137151188226247283303317355390424445483519532
5.394076200853651
Alfonso40087622083415777115155182221
F,424576220833339
Coughlan430176220834078117156195211244283
JC,46007622083256680
Giacoppo46977622083435992125163203243283
D,499776220834556
et507076220833457
al.51447622083324861
Management522276220835588127160199235294329368390
of394077210833757
in‑stent40117721083155376103127161200222
restenosis.42477721083215583106140179218245260287301
EuroIntervention.45627721083337091129146184206240262297332371393408447486500
2022;18(2):e103-23.507677210833468102137150180212232266284297332362394429453485522537