Interv Akut Kardiol. 2014;13(2):68-72

The significance of the analytic mean platelet volume determination in patients with the ischemic heart disease

Barbora Buliková¹, Lubomír Křivan², Petr Kala², Alena Buliková³, Petra Ovesná⁴, Jindřich Špinar²

¹ Lékařská fakulta MU Brno

² Interní kardiologická klinika FN Brno

³ Oddělení klinické hematologie FN Brno

⁴ Institut statistiky a analýz MU Brno

Objective: To explore the value of routine mean platelet volume (MPV) determination in patients with the acute coronary syndrome.

Methods: We compared MPV in 333 persons divided into two groups. In the first group, there were patients hospitalized with an acute

coronary syndrome (myocardial infarction or unstable angina pectoris). Second group was represented by patients with stable angina

pectoris and healthy blood donors. Analyzers Cell Dyn Saphire and XL 5000 were used to determine MPV.

Results: We proved statistically significant difference in the MPV value between patient with ACS and the group of healthy donors and

patient with stable angina pectoris. We defined MPV cut-off value for high risk of the acute coronary syndrome 9,86 fl with sensitivity

of 31,6 % and specificity of 89 %.

Conclusion: The MPV may be useful for diagnosis, therapeutic decision and also prognosis of the acute coronary syndrome.

Keywords: mean platelet volume, MPV, acute coronary syndrome, myocardial infarction, unstable angina pectoris, cardiovascular risk, percutaneous coronary intervention, dual antiplatelet therapy

Published: May 15, 2014  Show citation