Interv Akut Kardiol 2012; 11(5-6): 226-228

BioMimeTM Sirolimus eluting coronary stent

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BioMimeTM Sirolimus eluting coronary stent comes with a new idea of taking stents towards a biomimicry concept. The stent is built on an ultra-thin strut thickness (65 μm) cobalt chromium stent platform using an intelligent hybrid system of open and closed cells, allowing for a morphology-mediated expansion, while employing a well-known antiproliferant, Sirolimus, that is eluted from a biodegradable copolymer within 30 days and provides high coating integrity and a low coating thickness of up to 2 μm. The resultant stent demonstrates nearly 100% endothelialization in 30-day preclinical models and low MACE rates (< 5%) in clinical trials in a large group of patients after one year.

Keywords: sirolimus, drug-eluting stents, hybrid stent design, reduced vascular injury

Published: December 1, 2012  Show citation

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-. BioMimeTM Sirolimus eluting coronary stent. Interv Akut Kardiol. 2012;11(5-6):226-228.
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    References

    1. BioMime Sirolimus eluting stent. Unpublished data on file with Meril Life Sciences.
    2. Simon C, Palmaz JC, Sprague EA. Influence of topografy on endothelialization of stents: clues for new design. J Lon Term Eff Med Implants. 2000; 10: 143-151. Go to original source... Go to PubMed...
    3. Kastrati A, Schomig A, et al. Intra-coronary stenting and angiographic results: Strut thickness effect on restenosis outcome (ISAR STEREO) trial. Circulation 2001; 103: 2816-2821. Go to original source... Go to PubMed...
    4. Kastrati A, Pache J, Mehilli J, et al. Intracoronary stenting and angiographic results: Strut thickness effect on restenosis outcome (ISAR STEREO - 2) trial. J Am CollCardiol 2003; 41: 1283-1288. Go to original source... Go to PubMed...
    5. meriT-1 data. Primary safety and efficacy data in 30 patients. Dr. Sameer Dani presented during TCT 2011. San Francisco, USA.
    6. The meriT-2 data - real Word application of BioMime a multi-center trial. Dr. Ashok Seth presented during TCT 2011. San Francisco, USA.
    7. The meriT-3 data - r.eal Word application of BioMime a multi-center registry. Dr. R. K. Jain presented during NIC 2012. Cochin, India.

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